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Enteropathogenic escherichia coli (EPEC) and other pathogens in hospitalised children with diarrhoea.

by Rabi Biswas. / Publication date from spine. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 122-143). / PREFACE --- p.2 / ACKNOWLEDGEMENTS --- p.3 / CONTENTS --- p.4 / GLOSSARY --- p.9 / ABSTRACT --- p.11 / INTRODUCTION --- p.12 / Chapter 1.1. --- OVERVIEW --- p.12 / Chapter 1.2. --- OBJECTIVES OF THE STUDY --- p.14 / LITERATURE REVIEW --- p.15 / Chapter 2.1. --- BACKGROUND OF THE STUDY --- p.15 / Chapter 2.2. --- ESCHERICHIA COLI : OVERVIEW --- p.17 / Chapter 2.2.1. --- Morphology --- p.18 / Chapter 2.2.2. --- Cultural characteristics --- p.18 / Chapter 2.2.3. --- Biochemical reactions --- p.19 / Chapter 2.2.4. --- Antigenic Structure --- p.19 / Chapter 2.2.5. --- Identification --- p.20 / Chapter 2.2.6. --- Classification of coli --- p.20 / Chapter 2.3. --- HISTORY OF EPEC --- p.22 / Chapter 2.3.1. --- E. coli as a cause of diarrhoea --- p.22 / Chapter 2.3.2. --- The first use of the term EPEC --- p.23 / Chapter 2.3.3. --- EPEC as a separate category of E. coli --- p.24 / Chapter 2.4. --- PATHOGENESIS OF EPEC --- p.25 / Chapter 2.4.1. --- Plasmid encoded virulence properties --- p.25 / Chapter 2.4.2. --- Characteristic interaction with intestinal mucosa --- p.26 / Chapter 2.4.3. --- Production of toxins --- p.28 / Chapter 2.5. --- EPIDEMIOLOGY OF EPEC --- p.29 / Chapter 2.6. --- EPIDEMIOLOGY OF EPEC IN CHINA AND HONG KONG --- p.32 / Chapter 2.7. --- CLINICAL INFECTION BY EPEC AND MANAGEMENT --- p.33 / Chapter 2.7.1. --- Epidemiological syndromes --- p.33 / Chapter 2.7.2. --- Infective dose --- p.33 / Chapter 2.7.3. --- Incubation period --- p.33 / Chapter 2.7.4. --- Host factors --- p.33 / Chapter 2.7.5. --- Reservoirs of infection --- p.33 / Chapter 2.7.6. --- Routes of transmission --- p.34 / Chapter 2.7.7. --- Seasonal variation --- p.34 / Chapter 2.7.8. --- Mechanism of diarrhoea --- p.34 / Chapter 2.7.9. --- Histology --- p.35 / Chapter 2.7.10. --- Clinical features --- p.35 / Chapter 2.7.11. --- Treatment --- p.35 / Chapter 2.7.12. --- Prevention --- p.36 / Chapter 2.8. --- DETECTION OF EPEC: LABORATORY METHODS --- p.36 / Chapter 2.8.1. --- O/H Serotyping --- p.36 / Chapter 2.8.2. --- Adhesion assay --- p.37 / Chapter 2.8.3. --- EAF probe --- p.37 / Chapter 2.8.4. --- FAS (Fluorescein Actin Staining) test --- p.37 / Chapter 2.8.5. --- ELISA (Enzyme Linked Immunosorbent Assay) --- p.38 / Chapter 2.8.6. --- eaeA gene probe --- p.38 / Chapter 2.8.7. --- bfpA probe --- p.39 / Chapter 2.8.8. --- PCR (Polymerase Chain Reaction) --- p.39 / MATERIALS AND METHODS --- p.41 / Chapter 3.1. --- PATIENT RECRUITMENT AND DATA COLLECTION --- p.41 / Chapter 3.1.1. --- Study site --- p.41 / Chapter 3.1.2. --- Study design --- p.41 / Chapter 3.1.3. --- Study period --- p.42 / Chapter 3.1.4. --- Study population --- p.42 / Chapter 3.1.5. --- Selection of patients --- p.42 / Chapter 3.1.6. --- Inclusion criteria for cases --- p.43 / Chapter 3.1.7. --- Exclusion criteria --- p.43 / Chapter 3.1.8. --- Selection of control group --- p.43 / Chapter 3.1.9. --- Collection of stool specimens --- p.44 / Chapter 3.1.10. --- Treatment of the study-patients --- p.45 / Chapter 3.1.11. --- Collection of date --- p.45 / Chapter 3.1.12. --- Ethical approval --- p.46 / Chapter 3.2. --- LABORATORY METHODS --- p.47 / Chapter 3.2.1. --- IN PWHLABORATORY --- p.47 / Chapter 3.2.2. --- IN AFRIMS LABORATORY --- p.48 / Chapter 3.3. --- DATA MANAGEMENT AND STATISTICAL METHODS --- p.63 / RESULT --- p.64 / Chapter 4.1. --- DEMOGRAPHY OF THE PATIENTS --- p.64 / Chapter 4.1.1. --- Age distribution of the patients --- p.64 / Chapter 4.1.2. --- Sex distribution of the patients --- p.64 / Chapter 4.1.3. --- Ethnic origin of the patients --- p.65 / Chapter 4.1.4. --- Distribution of area of abode in Hong Kong --- p.66 / Chapter 4.1.5. --- School attendance of the patients --- p.66 / Chapter 4.2. --- PREDISPOSING FACTORS FOR DIARRHOEA --- p.67 / Chapter 4.2.1. --- History of breast feeding of the patients --- p.67 / Chapter 4.2.2. --- History of contact with diarrhoea --- p.68 / Chapter 4.2.3. --- Travel history within last two weeks preceding onset of diarrhoea --- p.68 / Chapter 4.2.4. --- Source of drinking water --- p.69 / Chapter 4.3. --- CLINICAL FEATURES --- p.70 / Chapter 4.3.1. --- Duration of diarrhoea at the time of admission --- p.70 / Chapter 4.3.2. --- Frequency of stool --- p.71 / Chapter 4.3.3. --- Nature and contents of stool --- p.72 / Chapter 4.3.4. --- Condition of the perineum --- p.72 / Chapter 4.3.5. --- Duration of vomiting at the time of admission --- p.73 / Chapter 4.3.6. --- Frequency of vomiting --- p.73 / Chapter 4.3.7. --- Level of dehydration in cases --- p.74 / Chapter 4.3.8. --- Urine output during illness --- p.74 / Chapter 4.3.9. --- Fever associated with illness --- p.75 / Chapter 4.4. --- HISTORY OF HOME- MANAGEMENT --- p.77 / Chapter 4.4.1. --- Main food taken at home during illness --- p.77 / Chapter 4.4.2. --- Supplementary fluid taken at home during illness --- p.77 / Chapter 4.4.3. --- Duration of hospital stay --- p.78 / Chapter 4.4.4. --- Recruitment of patients in different months --- p.79 / Chapter 4.5. --- RESULTS OF GENE PROBING FOR E. COLI --- p.80 / Chapter 4.6. --- DETAILS OF THE EAF+ EPEC CASES --- p.82 / Chapter 4.6.1. --- Associated infections in EAF+ cases --- p.83 / Chapter 4.7. --- AETIOLOGY OF DIARRHOEA --- p.84 / Chapter 4.7.1. --- Age distribution --- p.85 / Chapter 4.7.2. --- Seasonal distribution --- p.86 / Chapter 4.7.3. --- Clinical features --- p.87 / Chapter 4.7.4. --- Different groups of Salmonella --- p.88 / Chapter 4.7.5. --- Dual infection among enteropathogens isolated --- p.89 / DISCUSSION --- p.90 / Chapter 5.1. --- RISK FACTORS ASSOCIATED WITH DIARRHOEA --- p.91 / Chapter 5.1.1. --- Age and sex of the patients --- p.91 / Chapter 5.1.2. --- Nutritional status --- p.91 / Chapter 5.1.3. --- Breast feeding --- p.92 / Chapter 5.1.4. --- Travelling --- p.93 / Chapter 5.2. --- SEVERITY OF DIARRHOEA IN HONG KONG --- p.93 / Chapter 5.3. --- MOLECULAR EPIDEMIOLOGY OF EPEC IN HONG KONG --- p.94 / Chapter 5.3.1. --- EAF probe --- p.94 / Chapter 5.3.2. --- EAF and EPEC virulence --- p.95 / Chapter 5.3.3. --- eaeA probe --- p.96 / Chapter 5.3.4. --- FAS test --- p.97 / Chapter 5.3.5. --- bfpA probe --- p.97 / Chapter 5.3.6. --- Comparison and contrast among the probes --- p.97 / Chapter 5.3.7. --- Probes in the present study --- p.99 / Chapter 5.3.8. --- Role of serogrouping at present --- p.100 / Chapter 5.3.9. --- EPEC in Hong Kong --- p.100 / Chapter 5.4. --- PREVALENCE OF OTHER CATEGORIES OF E. COLI --- p.101 / Chapter 5.5. --- COMMON AETIOLOGY OF DIARRHOEA IN HONG KONG --- p.102 / Chapter 5.5.1. --- Rotavirus as the most common cause --- p.102 / Chapter 5.5.2. --- Non-typhoid Salmonella as the major bacterial pathogen --- p.102 / Chapter 5.5.3. --- Campylobacter and Shigella as cause of diarrhoea --- p.103 / Chapter 5.5.4. --- Role of parasites in childhood diarrhoea in Hong Kong --- p.104 / Chapter 5.6. --- CONTROL MEASURES FOR DIARRHOEAL DISEASES --- p.105 / Chapter 5.6.1. --- Prevention of diarrhoea through improved nutrition --- p.105 / Chapter 5.6.2. --- Fluid supplementation in diarrhoea --- p.106 / Chapter 5.6.3. --- Strategies to control diarrhoea --- p.106 / Chapter 5.6.4. --- Health education --- p.107 / CONCLUSION --- p.108 / APPENDIX --- p.109 / Chapter 7.1. --- QUESTIONNAIRE --- p.109 / Chapter 7.2. --- LABORATORY METHODS --- p.111 / Chapter 7.2.1. --- Routine culture of stool specimens for bacteria --- p.111 / Chapter 7.2.2. --- "Serotyping of Salmonella, Shigella and Vibrio cholerae" --- p.114 / Chapter 7.2.3. --- Microscopic examination of ova and cysts --- p.117 / Chapter 7.2.4. --- Laboratory diagnosis of rotavirus --- p.118 / Chapter 7.3. --- INVESTIGATION REQUISITION FORM --- p.121 / REFERENCES --- p.122 / GRADUATE SEMINARS & PUBLICATIONS --- p.144 / Chapter a. --- Graduate seminars --- p.144 / Chapter b. --- Publications --- p.144

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_321697
Date January 1996
ContributorsBiswas, Rabi., Chinese University of Hong Kong Graduate School. Division of Medical Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, 144 leaves : ill. (some col., some mounted) ; 30 cm.
CoverageHong Kong
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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