A dose related carcinogenic response was established for dimethylnitrosamine
administered in the diet of rainbow trout (Salmo gairdneri).
An equation was derived for the relationship between dose and hepatocellular
carcinoma incidence. From a published dose response study
using Porton rats as a test animal, a second equation was derived
for comparison. The rat and the trout were approximately equivalent
in their sensitivity to dimethylnitrosamine carcinogenesis. The
histological nature of the carcinogenic response in trout was similar to
to that of mammalian species. Apart from carcinogenesis, no indications
of chronic toxicity were observed after a one year feeding experiment.
The median lethal dose after intraperitoneal injection of
dimethylnitrosamine was 1,770 mg/kg body weight in rainbow trout.
Relative to the range of 15 to 50 mg/kg body weight reported for
several mammalian species, trout were resistant to the acutely
toxic effects of dimethylnitrosamine. / Graduation date: 1977
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27160 |
| Date | 17 September 1976 |
| Creators | Grieco, Mary Porter |
| Contributors | Scanlan, Richard A., 1937- |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
Page generated in 0.0017 seconds