Theranostics is connecting two medical branches, diagnostic and therapy. It enables transport of drugs and diagnostic imaging in one step. Nanoparticles, nanotubes, lipozomes or apoferritin can be used as platform for targeted transport. Apoferritin (APO) is a protein from ferritin family, which is characterized by an empty cavity. Is possible encapsulate some cargo (e.g., drug) into this cavity. Encapsulation is done by pH change. There is a possibility to modify APO surface. It causes targeted transport to for example cancer cells. In this study, process of preparation of targeted nanotransporter based on APO is described; next, its characterization by in vitro experiments is shown. The prepared targeted nanotransporter delivered drug to cancer cells and in the same time was decreased toxicity on surrounding tissue and organs.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:430574 |
| Date | January 2017 |
| Creators | Donovalová, Alexandra |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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