MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Description

Yes / Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Links & Downloads

1. Kalafatovic D, Nobis M, Javid N et al (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Sciences. 3(2): 246-249.
2. http://hdl.handle.net/10454/11430
3. https://doi.org/10.1039/C4BM00297K

Tags

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11430
Date	28 October 2014
Creators	Kalafatovic, D., Nobis, M., Javid, Nadeem, Frederix, P.W.J.M., Anderson, K.I., Saunders, B.R., Ulijn, R.V.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Published version
Rights	(c) 2015 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)