Zhang Jie. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves 54-74). / Abstracts in English and Chinese. / ACKNOWLEDGEMENTS --- p.i / ABSTRACT --- p.ii / ABSTRACT (Chinese) --- p.iv / ABBREVIATION --- p.vi / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter 1.1 --- Overview of the study --- p.1 / Chapter 1.2 --- Secretin --- p.3 / Chapter 1.2.1 --- Discovery / Chapter 1.2.2 --- Molecular biology / Chapter 1.2.3 --- Biosynthesis and localization / Chapter 1.2.4 --- Function / Chapter 1.3 --- Secretin receptor --- p.8 / Chapter 1.3.1 --- Molecular biology / Chapter 1.3.2 --- Localization / Chapter 1.3.3 --- Signal transduction pathway / Chapter 1.4 --- Secretin and autism --- p.13 / Chapter 1.5 --- AMPA receptor --- p.15 / Chapter 1.5.1 --- Molecular biology / Chapter 1.5.2 --- Localization / Chapter 1.5.3 --- Pharmacological property / Chapter 1.5.4 --- Function / Chapter 1.6 --- Cerebellum --- p.20 / Chapter 1.6.1 --- Structure of the cerebellar cortex / Chapter 1.6.2 --- Neurons of the cerebellar cortex / Chapter 1.6.2.1 --- Granule cells / Chapter 1.6.2.2 --- Purkinje cells / Chapter 1.6.2.3 --- Basket and stellate cells / Chapter 1.6.2.4 --- Golgi cells / Chapter 1.6.3 --- Intrinsic circuitry of the cerebellar cortex / Chapter CHAPTER 2 --- METHODS AND MATERIALS --- p.25 / Chapter 2.1 --- Brain slice preparation and maintenance --- p.25 / Chapter 2.2 --- Experimental set-up --- p.26 / Chapter 2.2.1 --- Visualization of neurons / Chapter 2.2.2 --- Electrophysiological recordings / Chapter 2.2.3 --- Evoked stimulation / Chapter 2.2.4 --- Drug preparation and administration / Chapter 2.3 --- Data analysis --- p.29 / Chapter 2.3.1 --- Construction of dose-response curve / Chapter 2.3.2 --- Analysis of synaptic currents / Chapter 2.3.3 --- Statistics / Chapter CHAPTER 3 --- RESULTS --- p.31 / Chapter 3.1 --- Basic characteristics of IPSCs recorded from PCs --- p.31 / Chapter 3.1.1 --- Spontaneous IPSCs / Chapter 3.1.2 --- Miniature IPSCs / Chapter 3.1.3 --- Evoked IPSCs / Chapter 3.1.4 --- Rundown of IPSCs / Chapter 3.2 --- Electrophysiological effects of secretin --- p.33 / Chapter 3.2.1 --- Effects of secretin on evoked IPSCs and EPSCs / Chapter 3.2.2 --- Effects of secretin on spontaneous IPSCs / Chapter 3.2.3 --- Effects of secretin on miniature IPSCs / Chapter 3.3 --- Mechanisms of secretin as a neuropeptide --- p.37 / Chapter 3.3.1 --- Non-involvement of a postsynaptic site of action / Chapter 3.3.2 --- Non-involvement of calcium influx / Chapter 3.3.3 --- Involvement of cAMP second messenger / Chapter 3.3.4 --- Involvement of presynaptic AMP A receptors / Chapter 3.3.4.1 --- Glutamate-mediated action of secretin / Chapter 3.3.4.2 --- Effects of AMPA on miniature IPSCs / Chapter 3.3.4.3 --- Pharmacological evidence / Chapter CHAPTER 4 --- DISCUSSION --- p.45 / Chapter 4.1 --- Secretin as a novel neuropeptide --- p.45 / Chapter 4.2 --- Mechanisms of secretin --- p.46 / Chapter 4.3 --- Physiological role of secretin in the cerebellum --- p.52 / Chapter 4.4 --- Secretin and autism --- p.52 / REFERENCES --- p.54
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_323624 |
| Date | January 2001 |
| Contributors | Zhang, Jie., Chinese University of Hong Kong Graduate School. Division of Physiology. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, vi, 74 leaves : ill. (some col.) ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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