Cutaneous leishmaniasis (CL) is usually a self-limiting lesion on the skin while visceral leishmaniasis is a progressive, systemic disease with high mortality even if treated. The problem associated with treatment and vector control justifies a search for an effective vaccine which seems to be the only practical means to control the disease. The aim of this study is to identify immunological surrogate marker(s) associated with protection against Leishmania infection. The results indicate that a single dose of ALM+BCG induced Thl-like response but the level of such response is not sufficient for full protection. Accordingly, further evaluation of the vaccine is necessary other strategies multiple injections or changing the adjutant.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc935616 |
| Date | 12 1900 |
| Creators | Mahmoodi, Majid |
| Contributors | O'Donovan, Gerard A., Khamesipour, Ali, Shanley, Mark Stephen, Theriot, L. J., Schneider, Daniel H. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | x, 174 leaves : ill., Text |
| Rights | Public, Mahmoodi, Majid, Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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