Stress has been shown to exacerbate cell death and cognitive deficits after ischemic
injury in rodents, however, little is known of the effects of stress on motor recovery. The
objective of this present thesis is to examine the effects of chronic stress on skilled motor
recovery after devascularization lesion in rats. It was found that pre-lesion stress induced
the most behavioural impairments, while post-lesion stress exacerbated infarct volume.
The effects of chronic multiple stress on skilled motor recovery after lesion was also
examined. Chronic multiple stress did not modulate skilled motor recovery nor did it
have any influence on infarct volume. Additionally, stress had effect on edema after
devascularization lesion. The present thesis suggests that the time of exposure to chronic
stress in respect to the ischemic lesion, in addition to the type of stress, will differentially
affect recovery and compensation in rats. / xii, 122 leaves : ill. ; 29 cm.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:ALU.w.uleth.ca/dspace#10133/387 |
| Date | January 2007 |
| Creators | Kirkland, Scott, University of Lethbridge. Faculty of Arts and Science |
| Contributors | Metz, Gerlinde |
| Publisher | Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007, Arts and Science, Department of Neuroscience |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Relation | Thesis (University of Lethbridge. Faculty of Arts and Science) |
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