The effect of increased egg consumption on plasma
cholesterol levels and its distribution among lipoproteins and
Apolipoprotein A-I/A-II ratios of high density lipoprotein
subfractions in individuals who did and did not demonstrate response
in plasma cholesterol levels was studied in 20 healthy middle-aged
men (30-55 years of age) for three months. Lunch containing 3 eggs
was fed all subjects during the first month classification period.
Subsequently, subjects were divided into hyper and hyporesponders
according to their blood cholesterol level. Thereafter, 6 eggs were
fed to hypo (n=12) while hyper (n=8) continued to consume 3 eggs
with lunch. The average plasma cholesterol level of the 20 subjects
was increased from 185±34 to 195±34 mg/lOOml during the
classification period. The mean plasma cholesterol level of the
hyperresponders was significantly (p<0.025) increased from 170±42 to
199±40 mg/100ml during classification while that of the
hyporesponders fell slightly. The additional 6 eggs consumed by the
hyporesponders for 6 weeks did not increase the mean plasma cholesterol level. The apoprotein ratios did not change as a result
of the increased cholesterol diet and were not significantly
different between the two response groups. The hyper and
hyporesponders differed significantly in initial plasma cholesterol
parameters that diminished as the subjects were challenged with
increased cholesterol consumption. These initial differences
included a significantly lower low density lipoprotein
cholesterol/high density lipoprotein cholesterol ratio of 2.26±0.6
for hyperresponders compared to 3.31±0.9 for hyporesponders. There
were also initial differences in the percentage of whole plasma
cholesterol found in the HDL fractions: hyperresponders had a
greater percentage of total and free cholesterol in the HDL and
HDL-2 fractions and a greater percentage of total cholesterol in the
HDL-3 fraction. The present data demonstrate that increased
cholesterol consumption will increase plasma cholesterol levels and
that there is individual variability of plasma cholesterol response
as a result of feeding cholesterol. / Graduation date: 1984
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27156 |
| Date | 16 November 1983 |
| Creators | Ward, Amy Sarver |
| Contributors | Oh, Suk Y. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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