Epilepsy, which manifests itself as spontaneous bouts of abnormal low complexity brain activity, is the second most common neurological disorder after stroke. This thesis explores the effect of variable frequency stimulation on seizure control. A responsive variable frequency electrical stimulation system is proposed and validated using a computational model capable of generating spontaneous seizure like events. The proposed stimulation system is demonstrated to outperform open-loop fixed frequency stimulation and responsive fixed frequency stimulation using seizure time based measures and a control energy
measure.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/24560 |
| Date | 22 July 2010 |
| Creators | Dian, Joshua Adam |
| Contributors | Bardakjian, Berj |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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