The use of nanotechnology is growing rapidly, with potential applications ranging from
production to electronics to medicine. Nanotechnology has been proven to have a great impact
on biomedicine through its applications in tissue engineering, cancer therapy, hyperthermia, and
other drug delivery purposes. Nanomaterials can be fabricated and manipulated to suit the
requirements for a particular function. Drug delivery through magnetic nanoparticles is being
used for site-specific and controlled drug-release purposes. Magnetic drug transport involves
encapsulating a drug in a magnetic nanosphere and administering it intravenously to deliver it to
a particular organ or a receptor for therapeutic purposes. Nanotechnology-based drug delivery
maximizes patient compliance and targeting efficiency, and thus reduces the toxicity of the drug
to normal cells. Nanotechnologies that are being used in medical applications for diagnostics, as
drug carriers, and for prosthesis and implants have raised interest and concern about their
biocompatibility and toxicity. It has been shown that nanomaterials that come in contact with the
human body can affect the central nervous system and cause inflammatory responses in the
lungs, liver, spleen, etc.
In this research, emphasis was placed on determining the toxicity of nanocomposite spheres
made from two magnetic nanoparticles—nickel ferrite and cobalt ferrite. These magnetic
nanoparticles were fabricated using a sol-gel process and then used to fabricate nanocomposite
spheres using PLGA as a polymer and an oil-in-oil emulsion/solvent evaporation technique.
Different samples were made with different nanoparticle compositions, and these samples were
tested for cytotoxicity using a standard colorimetric test using MTT assay. Viability tests were
conducted on these cells to determine the toxicity by varying the composition and concentration
of the nanoparticle, and then comparing the two different nanomaterials. / Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering.
| Identifer | oai:union.ndltd.org:WICHITA/oai:soar.wichita.edu:10057/3307 |
| Date | 05 1900 |
| Creators | Garikapati, Anusha |
| Contributors | Asmatulu, Ramazan |
| Publisher | Wichita State University |
| Source Sets | Wichita State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Format | xiii, 71 p., 3425182 bytes, 1843 bytes, application/pdf, text/plain |
| Rights | Copyright Anusha Garikapati, 2010. All rights reserved |
Page generated in 0.0014 seconds