Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified. / Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.
| Identifer | oai:union.ndltd.org:WICHITA/oai:soar.wichita.edu:10057/6117 |
| Date | 07 1900 |
| Creators | Tiew, Kok-Chuan |
| Contributors | Groutas, William C. |
| Publisher | Wichita State University |
| Source Sets | Wichita State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Format | xiv, 51 p. |
| Rights | Copyright Kok-Chuan Tiew, 2011. All rights reserved |
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