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Dengue virus protease inhibitors

Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified. / Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry.

Identiferoai:union.ndltd.org:WICHITA/oai:soar.wichita.edu:10057/6117
Date07 1900
CreatorsTiew, Kok-Chuan
ContributorsGroutas, William C.
PublisherWichita State University
Source SetsWichita State University
Languageen_US
Detected LanguageEnglish
TypeThesis
Formatxiv, 51 p.
RightsCopyright Kok-Chuan Tiew, 2011. All rights reserved

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