To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin.
Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-14848 |
Date | 01 December 1997 |
Creators | Fogelmark, Birgitts, Sjöstrand, Margarets, Williams, David, Rylander, Ragnar |
Publisher | Digital Commons @ East Tennessee State University |
Source Sets | East Tennessee State University |
Detected Language | English |
Type | text |
Format | application/pdf |
Source | ETSU Faculty Works |
Rights | http://creativecommons.org/licenses/by/4.0/ |
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