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Light induced engrams in in-vitro neuronal cultures

In the thesis is described the development of two platforms to optogenetically induce single neuron excitation and formation of memory in biological in-vitro neuronal networks.One platform is a photonic chip, with aperiodic grating scatterers able to create a specific light distribution on the surface of the chip. The second platform is a digital light processor device integrated in a microscopy setup, able to create on the sample plane whatever pattern with 3 um resolution. Stimulating simultaneously many neurons, it was demonstrated the ability of this system to induce potentiation on the illuminated cells, and thus engram formation.

Identiferoai:union.ndltd.org:unitn.it/oai:iris.unitn.it:11572/339576
Date28 April 2022
CreatorsZaccaria, Clara
ContributorsZaccaria, Clara, Pavesi, Lorenzo
PublisherUniversità degli studi di Trento, place:TRENTO
Source SetsUniversità di Trento
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/openAccess
Relationfirstpage:1, lastpage:102, numberofpages:102

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