M.Sc. (Chemistry) / Inhibition of mycothiol biosynthesis pathway has attracted attention from chemists and biochemists who aim to develop novel anti-TB drugs. A possible route to inhibit the production of mycothiol in cells may be via the inhibition of enzymes involved in the biosynthetic pathways. Molecular analogues that mimic mycothiol and containing tetrahedral-forming functional groups have been reported to show activity against mycothiol biosynthesis by inhibiting the enzymes in the mycothiol biosynthetic pathway...
Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uj/uj:7861 |
Date | 09 December 2013 |
Creators | Moshapo, Paseka Thendo |
Source Sets | South African National ETD Portal |
Detected Language | English |
Type | Thesis |
Rights | University of Johannesburg |
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