Cyclopropanation of the unsaturated fatty acid moieties of membrane phospholipids is a commonly observed phenomenon in a number of bacterial systems. The cyclopropane fatty acids are usually synthesized during and after the transition from exponential growth to stationary phase, or under such environmental conditions as acidic culture pH, low oxygen tension or high salt concentrations. S-Adenosylmethionine, the ubiquitous methyl group donor, provides the methylene bridge carbon in the reaction catalyzed by cyclopropane fatty acid synthase. Also formed in the reaction is S-adenosylhomocysteine, a potent inhibitor of cyclopropane fatty acid synthase, which is degraded by S-adenosylhomocysteine nucleosidase. This work provides evidence for at least two modes of regulation of lactobacillic acid synthesis, the cyclopropane fatty acid formed from cis-vaccenic acid (cis-11,12-octadecenoic acid), in Lactobacillus piantarum.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc331446 |
| Date | 12 1900 |
| Creators | Smith, Darwin Dennis |
| Contributors | Norton, S. J., Jacobson, Myron, Gracy, Robert W., Russell, Benny, Jones, Paul R. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | viii, 130 leaves : ill., Text |
| Rights | Public, Smith, Darwin Dennis., Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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