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Resolution of the Neutropenia of Felty's Syndrome by Longterm Administration of Recombinant Granulocyte Colony Stimulating Factor

Felty's syndrome is characterized by neutropenia, splenomegaly, and recurrent infection in patients with rheumatoid arthritis. We Used recombinant granulocyte colony stimulating factor (rGCSF) in a patient with Felty's syndrome and recurrent sepsis. rGCSF induced a statistically significant increase in the patient's absolute neutrophil and total white blood cell counts. During 14 months of followup taking rGCSF, disseminated varicella zoster was the only infectious complication. Except mild thrombocytopenia and a transient flare of arthritis, no serious adverse effects occurred. rGCSF may be a safe and effective therapy for Felty's syndrome in selected patients.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-12297
Date24 April 1996
CreatorsKrishnaswamy, Guha, Odem, Caroll, Chi, David S., Kalbfleisch, John, Baker, Neal, Smith, John Kelly
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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