The aim of this master thesis is to create a simple 3D electro-anatomical model of cardiac tissue that will be able to simulate the electrical activation in both a healthy heart and a heart with arrhytmogenic substrate. The model of electrical activation is realized in the COMSOL Multiphysics, simulation software for modelling using the finite element method. The Fitzhugh-Nagumo equation was used to model the excitatory feature of the myocardium and 2D models of myocardial tissue describing the propagation of action potential in healthy tissue, ischemic tissue, spontaneous action potential formation in the SA node, and spiral wave formation were first developed based on appropriate parameters. Subsequently, simplified 3D models of the heart describing the spread of excitement in a healthy heart, in the presence of accessory pathway and in third-degree atrioventricular block were created. The simplified 3D heart model offers a compromise between computational load and model complexity and can be used as a diagnostic tool for tissue and whole heart adjustment with appropriate equation parameter settings.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:400970 |
| Date | January 2019 |
| Creators | Míková, Monika |
| Contributors | Mézl, Martin, Hejč, Jakub |
| Publisher | Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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