Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Nikola Kopková Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Title of diploma thesis: Antiplatelet effects of flavonoids The most common antioxidants in ordinary food are flavonoids. They show antioxidant and anti-aggregation effects and other positive effects on cardiovascular diseases. Flavonoids are promising candidates to be antiplatelet drugs. Although several mechanisms responsible for antiplatelet activity have been suggesteed, only a few have been documented by published studies. The inhibition of blood platelet aggregation by flavonoids is reversible, which is another important factor. Data on thrombin-induced aggregation are controversial, some claim that flavonoids have no effect, the others says they have positive effects. (In the case of quercetin and genistein, inhibition of aggregation induced by thrombin was documented). The effect on arachidonic acid in the aggregation cascade is well documented, but there are several inconsistencies resulting from the use of different materials. Other mediators of aggregation are phospholipase A2, which plays a key role in the formation of inflammatory mediators. In this case, it has been shown that mainly genistein is capable of...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:370991 |
| Date | January 2017 |
| Creators | Kopková, Nikola |
| Contributors | Mladěnka, Přemysl, Jirkovský, Eduard |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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