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Reologické vlastnosti vazelíny bílé / Rheological properties of White Soft Paraffin

CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name of the student: Anna Hánová Title of diploma thesis: Rheological properties of White Soft Paraffin Consultant: PharmDr. Eva Šnejdrová, Ph.D. This diploma thesis deals with the evaluation of consistency and rheological properties of the Soft Paraffin after viscosity modification by either Liquid or Solid Paraffin. The theoretical part focuses the characteristics and application of the hydrocarbon excipients, their use in pharmacy and comparison with other substances, rheological properties of semisolids and their consistency. Consistency by penetrometry according the Czech Pharmacopoeia 2009 and rheological properties using Kinexus rheometer were measured. Consistency of Soft Paraffin was significantly influenced with 5 % of Liquid Paraffin and 10 % of Solid Paraffin. The result of consistency assessment is significantly influenced by the method of the samples preparation. Rheograms and viscosity curves was constructed. Plastic systems were described in detail by the parameters of power law model and yield stress value. The addition of 5 % of Liquid Paraffin to the Soft White Paraffin caused the decrease of the coefficient of consistency and the flow index. A further addition of Liquid...

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:331775
Date January 2015
CreatorsHánová, Anna
ContributorsŠnejdrová, Eva, Šiška, Bedřich
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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