Indiana University-Purdue University Indianapolis (IUPUI) / The majority of currently marketed fluoride varnishes (FV) have not been
evaluated for their effectiveness in preventing dental caries. Fundamental research on
FVs and how different formulations affect adherence to teeth, fluoride release into saliva
and uptake by teeth is virtually non-existent. The objective of this work was to
investigate the anti-caries potential, measured as fluoride release into saliva, change in
surface microhardness of early enamel caries lesions, and enamel fluoride uptake,
of multiple commercially available FVs. We have found that FVs differed in their release
characteristics, rehardening capability, and ability to deliver fluoride to demineralized
lesions. In addition to our in vitro work, we have conducted a clinical study that aimed to
compare saliva and plaque fluid fluoride concentrations following the application of three
commercially available FV treatments at predetermined post application time points. We
also investigated the change in fluoride concentration in saliva and plaque fluid fluoride
from baseline to each post application predetermined time point. We found that FVs
varied in their release of fluoride into saliva and plaque fluid but shared common trends
in release characteristics. The outcomes of our in vitro and in vivo investigations
demonstrate a great variation in anti-caries potential of FVs. This may be attributed
to different compositions and physical properties of the tested FVs.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/11002 |
| Date | 12 November 2015 |
| Creators | Al Dehailan, Laila Adel |
| Contributors | Martinez-Mier, Esperanza Angeles, Lippert, Frank, Soto-Rojas, Armando E., González-Cabezas, Carlos, Stelzner, Sarah |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Dissertation |
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