No / A neurological disorder is any disorder or abnormality in the nervous system. Among different neurological disorders,
Alzheimer’s disease (AD) is recognized as the sixth leading cause of death globally. Considerable research has
been conducted to find pioneer treatments for this devastating disorder among which cell therapy has attracted
remarkable attentions over the last decade. Up to now, targeted differentiation into specific desirable cell types
has remained a major obstacle to clinical application of cell therapy. Also, potential risks including uncontrolled
growth of stem cells could be disastrous. In our novel protocol, we used basal forebrain cholinergic progenitor cells
(BFCN) derived from human chorion-derived mesenchymal stem cells (hC-MSCs) which made it possible to obtain
high-quality population of cholinergic neurons and in vivo in much shorter time period than previous established
methods. Remarkably, the transplanted progenitors fully differentiated to cholinergic neurons which in turn integrated
in higher cortical networks of host brains, resulting in significant improvement in cognitive assessments. This
method may have profound implications in cell therapies for any other neurodegenerative disorders. / This work was carried outwithin the framework of a collaborative project (Project Grant No. 94-02-30-25922) by the School of Medicine, Iran University of Medical Sciences, (Project Grant No. REP209) council for stem cell sciences and technologies (Presidency of the Islamic Republic of Iran, vice-presidency for science and technology), and Iran National Science Foundation (INSF).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/16987 |
| Date | 16 March 2018 |
| Creators | Mohammadi, A., Maleki-Jamshid, A., Sanooghi, D., Milan, P.B., Rahmani, A., Sefat, Farshid, Shahpasand, K., Soleimani, Morteza, Bakhtiari, M., Belali, R., Faghihi, F., Joghataei, M.T., Perry, G., Mozafari, M. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text in the repository |
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