Made available in DSpace on 2014-12-17T14:44:18Z (GMT). No. of bitstreams: 1
MicheleVO_DISSERT.pdf: 9305862 bytes, checksum: 2d47288223836ac6ba52c9de6822c77f (MD5)
Previous issue date: 2013-12-11 / genetic and environmental factors contribute to the development of
cardiovascular risk and that influence can be differentiated by factors characteristic of
each population, age and sex. Aim: To investigate the heritability of anthropometric
and biochemical markers as predictors of cardiovascular risk in men and women of
different age groups, using the method of twins. Methods: A sample of 88 subjects
and of these 52 children and adolescents (08-17 years old) 32 monozygotic (20
female and 12 male) and 20 dizygotic (12 female and 08 male) and 36 adults (18-28
years age) 24 monozygotic (08 female and 16 male) and 12 dizygotic (06 female and
06 male), living in the metropolitan region of Natal / RN, Brazil. Anthropometric
measures were taken as the height, body mass, waist circumference (WC), sum of
skinfolds (ΣDC), fat percentage CUN-BAE, BMI and conicity. Biochemical markers
analyzed were: fasting glucose (GLU), total cholesterol (COL), HDL-C, LDL-C and
triglycerides (TG). After processing the data the index of heritability (h2) = (S ? MZ) / S
? DZ (DZ S ?) X100 was applied disaggregated by sex and age. Results: The
variables showed differential heritability of behavior for men and women, depending
on age. The variables with the highest heritability values were ΣDC, GLU, HDL, TG, in
men and BMI, WC, ΣDC, GLU, HDL-C and TG in women. And more influenced by the
environment variables were: body mass, BMI, Chol, LDL-C in men; body mass and
LDL-C in women. Conclusion: Differences index of heritability by gender for
cardiovascular risk predictors may assist in planning specific intervention strategies
according to gender and stage of life of that individual. It is from the level of
environmental influence that can run interventions for changes of components related
to cardiovascular risk / Os fatores gen?ticos e ambientais contribuem para o desenvolvimento do risco cardiovascular e essa influ?ncia pode ser diferenciada por fatores caracter?sticos de cada popula??o, idade e sexo. Objetivo: investigar a herdabilidade de vari?veis antropom?tricas e marcadores bioqu?micos como preditores do risco cardiovascular em homens e mulheres de diferentes faixas et?rias, utilizando o m?todo de g?meos. M?todos: Amostra composta por 130 g?meos, sendo do sexo feminino 42 monozigotos e 32 dizigotos e do sexo masculino 28 monozigotos e 28 dizigotos, residentes na regi?o metropolitana de Natal/RN, Brasil. Como medidas antropom?tricas foram aferidas a estatura, massa corporal, circunfer?ncia da cintura (CC), somat?rio de dobras cut?neas (∑DC), percentual de gordura CUN-BAE, IMC e ?ndice de conicidade. Os marcadores bioqu?micos analisados foram: glicemia de jejum (GLI), colesterol total (COL), HDL-C, LDL-C e triglicer?deos (TG). Ap?s o tratamento dos dados foi aplicado o ?ndice de herdabilidade (h2) = ((S? DZ S? MZ) / S? DZ) x 100; separado por sexo e idade. Resultados: As vari?veis apresentaram comportamento de hereditariedade diferenciado para homens e mulheres, dependendo da idade. As vari?veis com maior herdabilidade foram: ∑DC, GLI, HDL, TG, nos homens; e IMC, CC, ∑DC, GLI, HDL-C e TG nas mulheres. E as vari?veis mais influenciadas pelo ambiente foram: Massa, IMC, COL, LDL-C, nos homens; massa e LDL-C nas mulheres. Conclus?o: As diferen?as por sexo do ?ndice de herdabilidade para os preditores do risco cardiovascular podem auxiliar no planejamento de estrat?gias de interven??o espec?ficas de acordo com o sexo e est?gio da vida desse indiv?duo. ? a partir do n?vel de influ?ncia ambiental que poder? correr as interven??es para modifica??es dos componentes relacionados ao risco cardiovascular
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/14620 |
| Date | 11 December 2013 |
| Creators | Oliveira, Michelle Vasconcelos de |
| Contributors | CPF:47015578042, http://lattes.cnpq.br/4311626091295357, Dantas, Paulo Moreira Silva, CPF:88516857700, http://lattes.cnpq.br/0392766010188739, Cabral, Breno Guilherme de Ara?jo Tin?co, CPF:00804970475, http://lattes.cnpq.br/8399135324397066, Santos, Luciano Alonso Valente dos, CPF:02628901781, http://lattes.cnpq.br/9017927437502071, Lemos, Telma Maria Araujo Moura |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Educa??o F?sica, UFRN, BR, Movimento Humano, Cultura e Educa??o, Sa?de e Desempenho |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
Page generated in 0.0094 seconds