This thesis reports the results of genetic and molecular analysis of polytene region 38 of D. melanogaster. / A detailed genetic map of the region has been constructed through the complementation analysis of 22 genes with 37 deficiency stocks, providing 48 breakpoints. 44 of the breakpoints have been precisely mapped and separate the complementation groups into 16 distinct intervals. / Molecular characterisation was achieved using a combination of computational sequence analysis and experimental techniques. In this manner, 46 new transcription units and their developmental expression patterns were identified and the physical location of 7 deficiency breakpoints revealed. Links have been established between the genetic and the physical maps using STSs and sequence information from previously cloned genes. This allowed the possible correlation of 4 previously genetically defined genes to their transcription units.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29876 |
| Date | January 1999 |
| Creators | Butler, Heather. |
| Contributors | Suter, B. (advisor), Lasko, P. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Biology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001686553, proquestno: MQ55041, Theses scanned by UMI/ProQuest. |
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