The aim of this dissertation was to valorize the effect of various levels of taurine on the antioxidant status in rats body, monitor serum taurine and individual aminoacids in selectedorgans. This dissertation valorize the influence of taurine in the rats liver and brain after its application into feed mixtures. The effect of taurine was monitored on the ratio of GSH / GSSG,concentration of metallothionein and taurine. To this experiment were used 48 Wistar male rats, which were divided into eight groups (n = 6). During four weeks feed mixtures were given to these rats enriched with taurin eat a dose of 0, 1000, 1500, 2000 2500, 3000, 3500 and 4000 mg / kg / diet. Animals accepted diet and drinking water ad libitum. Average consumption of feed mixtures were 35 grams per day. Application taurine in creased concentration of taurine in the organism, which has an positive effect on antioxidant mechanisms of the organism. In deed we can not confirm that the addition of taurine in to the diet increases the concentrations of metallothionein and glutathione in the organism. In the brain was found increasing ratio of GSH / GSSG and reduced concentration of metallothionein. The other way around in the liver was reduction ratio of GSH / GSSG and increasing concentration of metallothionein.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:362749 |
| Date | January 2016 |
| Creators | Mrázková, Martina |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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