Yes / Smoking increases the risk of developing type 2 diabetes. However, several population studies also show
a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk
equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the
first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in
a population study, for how long this association persisted, and whether or not this association was mediated by
weight change.
Methods We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using
The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel
regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c,
and the mediating effect of weight change.
Findings 10 692 adult smokers with type 2 diabetes were included. 3131 (29%) quit smoking and remained abstinent
for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21% (95% CI 0·17–0·25; p<0·001;
[2·34 mmol/mol (95% CI 1·91–2·77)]) within the first year after quitting. HbA1c decreased as abstinence continued
and became comparable to that of continual smokers after 3 years. This increase in HbA1c was not mediated by weight
change.
Interpretation In type 2 diabetes, smoking cessation is associated with deterioration in glycaemic control that lasts for
3 years and is unrelated to weight gain. At a population level, this temporary rise could increase microvascular
complications.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/7930 |
| Date | 06 1900 |
| Creators | Lycett, D., Ryan, R., Farley, A., Roalfe, A., Mohammed, Mohammed A., Szatkowski, L., Coleman, T., Morris, R., Farmer, A., Aveyard, P., Nichols, L. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2015 Elsevier Ltd. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. |
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