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Previous issue date: 2010-08-17 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico, CNPq, Brasil. / Cases of diseases induced by toxic plants in domestic herbivores are well reported throughout
the world and have been studied also in Brazil. However, not much is known about the
epidemiological and pathological aspectos of these conditions in free-living wildlife or bred in
captivity. The risk for developing the toxicoses in captivity has been increasing, since natural
habitats are destroyed by human action, and more centers of wildlife conservation and
zoological comes are created. This study describes the epidemiological, biological and
clinicopathological, lectin-histochemical and ultrastructural aspects of an outbreak of
lysosomal storage disease of oligosaccharides induced by ingestion of Sida carpinifolia in
young Sambar deer (Cervus unicolor) in the Rio-Zoo Foundation in the State of Rio de
Janeiro, Brazil. Nine deer showed neurological signs characterized by motor and
proprioceptive deficits. Then neurological signs were mainly depression, incoordination,
dysmetria, ataxia, broad-based members, muscle tremors, loss of tongue tone, frequent falls
and death. Grossly hematomas were observed secondary to trauma caused by dominant males
of the flock, and whitish striations, especially in the renal cortex. Histologic changes included
marked swelling/cytoplasmic vacuolization especially in neurons, progressing to neuronal
lysis and axonal spheroids, in exocrine pancreas, thyroid follicular cells and renal tubular
epithelial cells. In the lectin-histochemical examination the vacuoles were formed by the
accumulation of oligosaccharides specially marked by the lectins WGA, WGA and Con-A.
Ultrastructurally, the swelling/vacuolation corresponded to intense cytoplasmic distention of
lysosomes, formation of residual bodies or dense granular fragments of membranes and
mielinoides bodies. The study has shown the susceptibility of Cervus unicolor to swainsonine
by ingestion of S. carpinifolia. Possibly poisoning the animals in this study was conducted by
food restriction by the hierarchy among males in the group. It might also determine the
marked similarity between clinical and pathological aspects in Sambar deer with the one
presented by other herbivores. / Casos de doen?as induzidas por plantas t?xicas em herb?voros dom?sticos s?o bastante
relatados por todo o mundo e v?m sendo estudados tamb?m no Brasil. Pouco se sabe,
contudo, sobre os aspectos epidemiol?gicos e patol?gicos dessas condi??es em animais
selvagens de vida livre ou criados em cativeiro. Os riscos de desenvolvimento dessas
toxicoses em cativeiros v?m aumentando, conforme os habitats naturais s?o destru?dos pela
a??o humana, e mais centros de conserva??o de vida silvestre e zool?gicos s?o criados. Nesse
estudo s?o descritos os aspectos epidemiol?gicos, biol?gicos e clinicopatol?gicos, lectinohistoqu?micos
e ultraestruturais de um surto de doen?a do armazenamento lisossomal de
oligossacar?deos induzido pela ingest?o de Sida carpinifolia em cervos Sambar jovens
(Cervus unicolor) no zool?gico da Funda??o Rio-Zoo no Estado do Rio de Janeiro. Nove
cervos apresentaram sinais cl?nicos neurol?gicos caracterizados por d?ficits proprioceptivo e
motor. Os sinais neurol?gicos inclu?ram principalmente depress?o, incoordena??o, dismetria,
ataxia, membros em base ampla, tremores musculares, perda do t?nus lingual, quedas
frequentes e morte. Macroscopicamente foram observados hematomas, secund?rios a traumas
provocados por machos dominantes do rebanho, e estria??es esbranqui?adas, principalmente
no c?rtex renal. As les?es histol?gicas inclu?am acentuada tumefa??o/vacuoliza??o
citoplasm?tica especialmente em neur?nios, p?ncreas ex?crino, c?lulas foliculares da tireoides
e do epit?lio renal, necrose neuronal com evolu??o para lise e esferoides axonais. Pelo exame
lectino-histoqu?mico os vac?olos eram formados por ac?mulo de oligossacar?deos marcado
especialmente pelas lectinas S-WGA, WGA e Con-A. Ultraestruturalmente, a
tumefa??o/vacuoliza??o citoplasm?tica correspondeu ? intensa distens?o de lisossomos,
forma??o de corpos residuais densos ou granulares, fragmentos de membranas e corpos
mielinoides. O estudo demonstrou a suscetibilidade de Cervus unicolor ? swainsonina contida
na S. carpinifolia. Possivelmente, a intoxica??o nos animais deste estudo ocorreu pela
restri??o alimentar sofrida pelos animais mais jovens, decorrente da hierarquia entre machos
no grupo. P?de-se determinar ainda a marcada similaridade do quadro cl?nico e patol?gico
entre os cervos descritos nesse trabalho e outros herb?voros dom?sticos.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/2252 |
| Date | 17 August 2010 |
| Creators | Anjos, Bruno Leite dos |
| Contributors | Peixoto, Paulo Fernando de Vargas, Fran?a , Ticiana do Nascimento, Tokarnia, Carlos Hubinger, Dobereiner, Juger, Carvalho, Eul?gio Carlos Queir?z, Varaschin, Mary Susan |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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