Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts. This makes hyaluronan, which can be biotechnologically produced in large scale, an attractive starting polymer for chemical modifications. This review provides a broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide. We discuss current advances and challenges of derivatization reactions targeting the primary and secondary hydroxyl groups or carboxylic acid groups and the N-acetyl groups after deamidation. In addition, we give examples for approaches using hyaluronan as biomedical polymer matrix and consequences of chemical modifications on the interaction of hyaluronan with cells via receptormediated signaling. Collectively, hyaluronan derivatives play a significant role in biomedical research and applications indicating the great promise for future innovative therapies.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:90992 |
| Date | 16 May 2024 |
| Creators | Hintze, Vera, Schnabelrauch, Matthias, Rother, Sandra |
| Publisher | Frontiers Media |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2296-2646, 830671, 10.3389/fchem.2022.830671, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/TRR 67: Funktionelle Biomaterialien zur Steuerung von Heilungsprozessen in Knochen- und Hautgewebe - vom Material zur Klinik/59307082//Synthese und Bereitstellung oligomerer und polymerer Glykosaminoglykan-Derivate sowie artifizieller extrazellulärer Matrizes /Z03, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/TRR 67: Funktionelle Biomaterialien zur Steuerung von Heilungsprozessen in Knochen- und Hautgewebe - vom Material zur Klinik/59307082//Entwicklung und Charakterisierung artifizieller extrazellulärer Matrizes auf der Basis von Kollagen und Glykosaminoglykan-Derivaten /A03 |
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