No / A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4618 |
| Date | 17 March 2008 |
| Creators | Stavri, M., Matthew, K.T., Gordon, Andrew, Shnyder, Steven, Falconer, Robert A., Gibbons, S. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text in the repository |
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