BACKGROUND:To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.METHODS:A retrospective review of 52 patients undergoing radiotherapy for head and neck cancers with image guidance based on daily megavoltage CT imaging with helical tomotherapy was performed.RESULTS:Mean contralateral parotid dose and the volume of the contralateral parotid receiving 40Gy or more were compared between radiotherapy plans with significant constraint (SC) of less than 20Gy on parotid dose (23 patients) and the conventional constraint (CC) of 26Gy (29 patients). All patients had PTV coverage of at least 95% to the contralateral elective neck nodes. Mean contralateral parotid dose was, respectively, 14.1Gy and 24.7Gy for the SC and CC plans (p<0.0001). The volume of contralateral parotid receiving 40Gy or more was respectively 5.3% and 18.2% (p<0.0001)CONCLUSION:Tomotherapy for head and neck cancer minimized radiotherapy dose to the contralateral parotid gland in patients undergoing elective node irradiation without sacrificing target coverage.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/610349 |
| Date | January 2012 |
| Creators | Nguyen, Nam, Vos, Paul, Vinh-Hung, Vincent, Ceizyk, Misty, Smith-Raymond, Lexie, Stevie, Michelle, Slane, Benjamin, Chi, Alexander, Desai, Anand, Krafft, Shane, Jang, Siyoung, Hamilton, Russ, Karlsson, Ulf, Abraham, Dave |
| Contributors | Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA, Biostatistics, East Carolina University, Greenville, NC, USA, Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland, Department of Radiation Oncology, University of West Virginia, Morgantown, VA, USA, Department of Radiation Oncology, University of Pittsburg, Pittsburg, PA, USA, Department of Radiation Oncology, Marshfield Clinic, Marshfield, WI, USA, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724-5081, USA |
| Publisher | BioMed Central |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | © 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) |
| Relation | http://www.biomedcentral.com/1471-2407/12/175 |
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