Only a minority of women with a human papillomavirus (HPV) infection eventually develop cervical cancer. This suggests a role for immune mechanisms in viral acquisition and clearance, most notably presentation of HPV antigens as mediated by gene products of the human leukocyte antigen (HLA) complex. / A longitudinal cohort investigation of cervical HPV infections was utilized to examine the role of selected HLA class I and II alleles in determining risk of HPV positivity and persistence for students attending McGill and Concordia universities in Montreal. HPV positivity was measured at baseline and then once every six months for a period of two years. Five hundred and fifty-nine women were identified for analysis. Five HLA alleles: B*07, DQB1*03, DQB1*0602, DRB1*13, and DRB1*1501 were typed using DNA extracted from cervical specimens sampled at enrollment. / In multivariate logistic regression analyses DRB1*13 (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.0-4.0) and DRB1*1501 (OR: 2.1; CI: 1.1-4.1) were associated with HPV 16 positivity. Women with DRB1*13 were also more likely to be positive for high-risk (HR) HPV infections (OR: 1.7; CI: 1.0-2.9), or H PV infection of any type (OR: 1.7; CI: 1.0-2.8). Most associations became stronger in the subset of women restricted on the basis of high likelihood to prior HPV exposure. / These results support the hypothesis that certain HLA class II polymorphisms mediate genetic susceptibility to HPV infection in young women.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.81428 |
| Date | January 2004 |
| Creators | Robinson, Keira |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002166604, proquestno: AAIMR06443, Theses scanned by UMI/ProQuest. |
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