A sensitive method measuring indium levels >1 ppb (ng/ml) in biological tissues was developed using graphite furnace atomic absorption spectrophotometry. Single oral and pulmonary exposure of uniformly sized indium phosphide particles (mean count diameter = 1.73 ± 0.85 μm) to rats at three dose levels. Indium was deposited throughout tissues after 4 days. Bone, hair, skin, liver and kidney contained the largest indium concentrations (ng Indium/gram tissue) in both studies. Total percent dose found in tissues by either route resulted in an estimated absorption of <0.5% (not including lung for pulmonary study) except in the oral low dose group. Here the percent dose found in tissues was about 5.0% of the administered dose. The lung retained >50% of the administered dose four days following intratracheal instillation. The major route of indium elimination for both oral and pulmonary studies was in the feces; >78% of the administered dose by two days following oral gavage and >26% of the administered dose following intratracheal instillation.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/291365 |
| Date | January 1991 |
| Creators | Monteleone, Jonathan Patrick, 1966- |
| Contributors | Carter, Dean E. |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Thesis-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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