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Previous issue date: 2006-08-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / It is recognized the role of prostaglandins in lowering de intraocular pressure, and more
recently, the observation of constitutive expression of COX-2 in the healthy eyes and the
absence of this isoenzyme in glaucomatous eyes. These discoveries bring the hypothesis that
the use of anti-inflammatory drugs may cause, as unwanted effects, ocular hypertension
through the inhibition of COX expression and the reduction of prostaglandins production. The
increase of intraocular pressure, even in a transient way, is a risk factor for the development
of the glaucoma. In order to observe a possible ocular hypertension associated with the use of
anti-inflammatory drugs, 28 beagle dogs were selected from the kennel of the Laboratory of
Development of Parasiticide Products, Department of Animal Parasitology, Veterinary
Institute, Universidade Federal Rural do Rio de Janeiro. On day 0 (zero) the totality of
animals had their intraocular pressure measured using applanation tonometry at 8 a.m. and 4
p.m., for evaluation of intraocular pressure before treatment; on the following day 10 animals
received meloxican, associated with wet feeding, on dosage of 0.2 mg Kg-1 and 0.1 mg weight
on the remainder of the four days, nine dogs received prednisone, associated with wet feeding,
on dosage of 1,0 mg Kg-1 during five days and nine dogs received only wet feeding. On the
fifth day of treatment the totality of dogs had their intraocular pressure measured again using
applanation tonometry at 8 a.m. and 4 p.m. For all groups, including control-group, the
highest average values of intraocular pressure were observed on day 5 (five). The difference
between intra-ocular pressure mensurations of the 08 hours and of the 16 hours was
significant, independent of treatment and of the considered day. The use of both steroidal or
non-steroidal anti-inflammatory were not capable of causing ocular hypertension and some
factors can be incriminated, such as route of administration, dosage and duration of therapy
chosen, besides genetic inheritance and absence of glaucomatous disorder between the
selected dogs. / ? reconhecido o papel hipotensor ocular das prostaglandinas e mais recentemente, a
observa??o da express?o de COX-2 constitutiva em olhos saud?veis e aus?ncia desta
isoenzima em olhos glaucomatosos. Estas descobertas geram a hip?tese de que o uso de
antiinflamat?rios apresente como efeito colateral, a hipertens?o ocular pela inibi??o da
express?o da COX e diminui??o da produ??o de prostaglandinas. O aumento de press?o
intra-ocular, mesmo que transit?rio, ? um fator de risco para o desenvolvimento do glaucoma.
Para poss?vel observa??o da hipertens?o ocular com o uso de antiinflamat?rios, foram
selecionados 28 c?es da ra?a beagle pertencentes ao Canil do Laborat?rio de
Desenvolvimento de Produtos Parasiticidas do Departamento de Parasitologia Animal do
Instituto de Veterin?ria da Universidade Federal Rural do Rio de Janeiro. No dia 0 (zero)
todos os animais tiveram a press?o intra-ocular mensurada com o uso do ton?metro de
aplana??o ?s 08 horas e ?s 16 horas, para avalia??o da press?o intra-ocular antes do
tratamento; no dia seguinte dez c?es receberam meloxicam, junto ? por??o de ra??o ?mida, na
dosagem de 0,2 mg/Kg e 0,1mg/Kg nos restantes quatro dias, nove c?es receberam
prednisona, junto ? por??o de ra??o ?mida, na dosagem de 1,0 mg/Kg durante cinco dias e
nove c?es receberam somente a por??o de ra??o ?mida. No quinto dia do tratamento todos os
animais tiveram novamente a press?o intra-ocular mensurada com o uso do ton?metro de
aplana??o ?s 08 horas e ?s 16 horas. Em todos os grupos, incluindo o grupo-controle, as
maiores m?dias de press?o intra-ocular foram observadas no dia 5 (cinco). A diferen?a dos
valores de press?o intra-ocular observada entre as medi??es das 08 horas e das 16 horas foi
significativa, independente do tratamento e do dia considerado. O uso dos antiinflamat?rios
esteroidal e n?o-esteroidal n?o foi capaz de causar hipertens?o ocular e alguns fatores podem
ser incriminados, como via de administra??o, dosagem e dura??o do tratamento utiliz ados,
al?m da heran?a gen?tica e aus?ncia de doen?a glaucomatosa nos c?es selecionados.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/907 |
| Date | 25 August 2006 |
| Creators | Souza, Maria Alice Fusco de |
| Contributors | Botteon, Paulo de Tarso Landgraf, Pereira, Jo?o Telhado |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Curso de P?s-Gradua??o em Medicina Veterin?ria, UFRRJ, Brasil, Cl?nica e Cirurgia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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