Chemical investigation of the soft coral Cladiella hirsuta, collected off
the coast of Penghu Islands, has led to the isolation of natural products
including ten new compounds hirsutalins A-D (1, 2, 3, 5) and
hirsutosterols A-F (6, 7, 8, 9, 10, 11), and one known compound
3-butanoyloxycladiell-11(17)-en-6,7-diol (4).
All of the chemical structures were established by detailed spectral
data analysis (NMR, IR, MS) and by comparison of the spectral data with
those of the related known compounds. The absolute structure of
compound 1 was determined applying a modified Mosher¡¦s method.
On the part of the cytotoxicity assay with six human cancer cell lines,
HepG2 (liver cancer cell), Hep3B (liver cancer cell), Ca9-22 (mouth cavity
cancer cell), A549 (lung cancer cell), MCF7 (breast cancer cell) and
MDA-MB-231 (breast cancer cell), compound 5 showed the significant
cytotoxicity against the cancer cell line HepG2; compound 7 showed the
moderate cytotoxicity against all of the above cancer cell lines; compounds
6, 8 and 10 also showed the moderate cytotoxicity against two of them,
Hep3B and Ca9-22. The products 6a and 7a , obtained by hydorlysis of 6
and 7, respectively, did not show obvious difference in cytotoxity by
comparison of the IC50 values of compounds 6 and 7.
On the part of anti-inflammation assay, compound 2 showed the
effectively inhibiting activity against the induced iNOS and COX-2
proteins. Compound 3 showed nearly the same activity against the induced
iNOS protein as that of 2.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0908109-173103 |
| Date | 08 September 2009 |
| Creators | Chang, Shu-ming |
| Contributors | Fang-Rong Chang, Ping-Jyun Sung, Yang-Chang Wu, Jyh-Horng Sheu |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908109-173103 |
| Rights | not_available, Copyright information available at source archive |
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