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The Total Synthesis of Depsilairdin

Dessertation describes of the first reported syntheses of the natural products lairdinol A and depsilairdin. The key steps in the synthesis of depsilairdin were N-terminal extension (C←N) of the protected proline fragment, hydrolysis of the tetrapeptide fragment with free secondary alcohol in the proline moiety and esterification of the HOBt ester of tetrapeptide fragment with the bromomagnesium alkoxide of lairdinol A.

Identiferoai:union.ndltd.org:USASK/oai:usask.ca:etd-12152009-175940
Date15 January 2010
CreatorsPardeshi, Sandip Govindsing
ContributorsUrquhart, Stephen, John, Balsevich, Ward, Dale E, David, Palmer, Michel, Gravel
PublisherUniversity of Saskatchewan
Source SetsUniversity of Saskatchewan Library
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://library.usask.ca/theses/available/etd-12152009-175940/
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