Anorexia nervosa is the third most common illness among adolescent females. Approximately one half the cases of anorexia nervosa have been suggested to be activity-induced. Various animal studies have been used to study human anorexia, particularly the activity-based anorexia model (ABA). The ABA paradigm consists of diet restriction and liberal access to activity, which ultimately results in a rapid decrease in both body weight and food intake paradoxical to the significant increase in activity. Because resistant starch (RS) has been shown to initiate a lower rise and a steady level of post-prandial blood glucose, it was hypothesized that a diet containing RS would reduce the severity of the anorexia associated with the ABA model. In this study, 56 five-wk old male Sprague-Dawley rats were assigned to 8 groups. Animals were fed a control diet (C-diet) or a RS-diet, on an ad libitum or a restricted-feeding (one 90min meal per day) schedule, and allowed 22-hr of access or no access to activity wheels. The study ended when majority of the ABA rats reached <75% of their pre-experimental bodyweights. Within 4 days of the experiment, ABA rats on the RS-diet lost an average 66g of bodyweight compared to an average loss of 31g in the C-diet (p<0.01). ABA rats on the RS-diet ran 31% more (NS), despite consuming 30% fewer calories per kg body weight, than those on the C-diet (p<0.01). ABA rats fed the RS-diet had 3.97 times higher levels of plasma norepinephrine (NE) compared to their associated controls (p<0.0001); ABA rats fed the C-diet had only 1.4 times the NE level of their corresponding controls (NS). All RS-fed rats had an average of 17-50% less fat pad (brown, perirenal, epididymal, & retroperitoneal) weights compared to C-fed rats (p<0.02). Resistant starch exacerbates rather than mitigates the responses to the ABA paradigm.
| Identifer | oai:union.ndltd.org:LSU/oai:etd.lsu.edu:etd-04082004-163913 |
| Date | 14 April 2004 |
| Creators | Nguyen, Holly M. |
| Contributors | Roy J. Martin, Maren Hegsted, Mike Keenan |
| Publisher | LSU |
| Source Sets | Louisiana State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lsu.edu/docs/available/etd-04082004-163913/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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