This diploma thesis is focused on biocompatible polymers degradation study. Copolymers were studied based on poly(lactic-co-glycolic) acid and poly(ethylene glycol) PLGA-PEG-PLGA and further these copolymers modified with itaconic acid ITA-PLGA-PEG-PLGA-ITA. This paper investigated the influence of pH phosphate solution on the degradation of polymers. Degradation of polymers occurred at 37 °C in phosphate solution with pH 4.2, 7.4 and 9.2. High performance liquid chromatography with UV-VIS detection of diode-array type was used for quantitative determination of lactic acid and glycolic acid as the final degradation products. For qualitative identification of additional degradation products were used tandem connection liquid chromatography and mass spectrometry. Gel permeation chromatography with refractive index detector was used to determine the molecular weight decrease polymer chain after the degradation.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:216802 |
| Date | January 2011 |
| Creators | Oborná, Jana |
| Contributors | Čáslavský, Josef, Vávrová, Milada |
| Publisher | Vysoké učení technické v Brně. Fakulta chemická |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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