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The Relationship of Force on Myosin Subfragment 2 Region to the Coiled-Coiled Region of the Myosin Dimer

The stability of myosin subfragment 2 was analyzed using gravitational force spectroscopy. The region was found to destabilize under physiological force loads, indicating the possibility that subfragment 2 may uncoil to facilitate actin binding during muscle contraction. As a control, synthetic cofilaments were produced to discover if the observations in the single molecule assay were due to the lack of the stability provided by the thick filament. Statistically, there was no difference between the single molecule assay data and the synthetic cofilament assay data. Thus, the instability of the region is due to intrinsic properties within subfragment 2.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc103322
Date12 1900
CreatorsHall, Nakiuda M.
ContributorsRoot, Douglas D., Benjamin, Robert C., Kunz, Dan
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
FormatText
RightsPublic, Hall, Nakiuda M., Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved.

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