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An Investigation of the Ratio of Free to Bound Phenytoin in Overdose Cases

An investigation of the ratio of free to bound phenytoin in overdose cases was accomplished by three studies to answer these questions: 1. Will the free to bound ratio change with increasing total phenytoin concentration? 2. Will the free to bound ratio be altered with decreasing total protein concentration? 3. Do these results correlate with overdose cases? The results demonstrated that the ratio of free to bound phenytoin remains constant throughout the therapeutic range as long as a person has a normal total protein concentration. However, the free to bound ratio changes significantly when the total protein decreases by 25 per cent. This substantiates the importance of monitoring free and total phenytoin concentrations in hypoproteinemia.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc501077
Date08 1900
CreatorsBeckman Royder, Mona Lee
ContributorsWimbish, Gary Harold, Sinclair, Richard J., Quist, Eugene
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvii, 56 leaves: ill., Text
RightsPublic, Beckman Royder, Mona Lee, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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