A model for experimental cecal and hepatic amebiasis was developed and characterized in the gerbil (Meriones unguiculatus). Pathogenic and non-pathogenic Entamoeba histolytica strains were shown to cause damage in the cecum, proportional to their previous behavior in humans. Secretion of intestinal mucus, crypt hyperplasia and cytolysis of interglandular epithelium were prerequisites for amebic invasion. Ulcerative lesions with destruction of mucosal and submucosal tissues led to amebic dissemination to the liver. Formation of amebic liver abscesses followed subacute changes in the liver. Liver lesions resulted from the cytolytic effects of the enzymes of destroyed neutrophils. Growth of liver abscesses followed cytolysis of the fibrogranuloma walls. Immunodepression in amebiasis was confirmed by serologic findings and histologic alterations in the lymph nodes and spleen, and by a lowered antiamebic effect of lymphoid cells in vitro. A neutrophil stimulating and chemotactic factor from pathogenic amebic membranes was isolated and characterized. It was shown that both host and parasite factors are involved in the pathogenesis and pathology of amebiasis.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.72069 |
| Date | January 1985 |
| Creators | Chadee, Khrisendath. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Institute of Parasitology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000230909, proquestno: AAINL24072, Theses scanned by UMI/ProQuest. |
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