This thesis is focused on analysis of immune processes during cancer immunotherapy which is based on synergistic combination of TLR agonists and phagocytosis stimulating ligands anchored into the tumour cell membrane. This immunotherapy was tested in murine melanoma B16-F10 and murine pancreatic adenocarcinoma Panc02 models. The aims of this thesis were to analyse the tumor infiltration, elucidate the role of innate immunity in this immunotherapy, and study the possibility of strengthening immunotherapeutic effect using anti-CD40 and anti-CTLA-4.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:375927 |
| Date | January 2018 |
| Creators | UHER, Ondřej |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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