A research report submitted to the School of Public Health, Faculty of Health Sciences,
University of the Witwatersrand, in partial fulfilment of the requirements of the degree
of
Masters in Science in Epidemiology and Biostatistics
Johannesburg, April 2013 / Haemophilus influenzae type b disease (Hib) was a major cause of childhood disease but has
nearly been eliminated in developed countries after the introduction of Hib conjugate vaccine. An
increase in non-typeable H. influenzae (NTHi) disease was observed in some countries post-Hib
vaccination which prompted concerns about possible serotype replacement. Hib disease in
children <5 years of age decreased by a minimum estimate of 71% in South Africa after the Hib
vaccine introduction in 1999. The epidemiology of Hib disease among persons >5 year olds and
NTHi disease in all ages has not been described in South Africa before. The aim of this study is
therefore to describe the trends and factors associated with invasive Hib and NTHi disease in
South Africa, 2003-2009 among persons of all ages.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/13947 |
| Date | 04 1900 |
| Creators | Fortuin-de Smidt, Melony Cathlin |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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