<p>Dry Powder inhalers (DPIs) have
been one of the most promising developments in pulmonary drug delivery systems.
In general, DPIs are more effective than systemic administrations and convenient
to use. However, delivering high-dose antibiotics through a DPI is still a
challenge because high powder load may need a very large inhaler or increase
the incidence of local adverse effects. Spray drying has been increasingly
applied to produce DPI formulations for high-dose antibiotics; nevertheless,
many spray-dried particles are amorphous and physically unstable during
storage, particularly under the humid environment. </p>
<p> </p>
<p>My research focuses on addressing
critical challenges in physical stability of DPIs for spray-dried high-dose
antibiotics. The effects of moisture-induced crystallization on physical
stability and aerosol performance of spray-dried amorphous Ciprofloxacin DPI
formulations stored at different humidity conditions were studied. Our study
not only provided a mechanistic understanding in the impact of crystallization
on aerosol performance but also developed novel approaches for improving
stability of spray-dried formulations used in DPI.</p>
<p> </p>
<p>Our work has shown that
recrystallization of amorphous spray-dried Ciprofloxacin led to significant
changes in aerosol performance of DPIs upon storage, which cause critical
quality and safety concerns. These challenges have been solved through co-spray-drying
Ciprofloxacin with either excipient such as leucine or synergistic antibiotic
like Colistin. Co-spray-drying Ciprofloxacin with Colistin not only improved
physical and aerosol stability but also enhanced antibacterial activity which
is a great advantage for treating ‘difficult to cure’ respiratory infections
caused by multidrug resistant bacteria.</p>
<p> </p>
<p>My research work is a sincere
effort to maximize the utility and efficacy of high-dose DPI, an effective
delivery tool for treating severe resistant bacterial respiratory infections.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/8872736 |
| Date | 15 August 2019 |
| Creators | Nivedita J Shetty (6955364) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Effect_of_Storage_Humidity_on_Physical_Stability_and_Aerosol_Performance_of_Spray-Dried_Dry_Powder_Inhaler_Formulations/8872736 |
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