Anatomical variability of the human insula has not been well studied because the structure of the insula is difficult to image. Thus, the aim of this study was to apply a novel method to reconstruct insular topology in order to assess the anatomic variation within a population. An analysis of 60 healthy male and female subjects revealed a significant amount of anatomic variation. Some structures, such as the central sulcus were extremely stable and showed little inter-individual variability, while other structures such as the middle short gyrus were highly variable, being more conspicuous in the left hemisphere and in males. Grey matter in the cortex was found to be thinner in the left posterior and dorsal insular subregions in older female subjects but not males. This work shows that the insula is an anatomically complex and variable structure and that some of the variability is related to sex and laterality.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33499 |
| Date | 26 November 2012 |
| Creators | Rosen, Allison |
| Contributors | Hodaie, Mojgan |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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