The availability of large amounts of genetic data from the mitochondrial DNA of species has created an unprecedented opportunity for the study of evolutionary processes. Being our closest relatives on the evolutionary tree the primates are a prime candidate for the study of evolutionary processes. The availability of large amounts of genetic data from the primates allows us to study and compare results from different phylogenetic reconstruction methods and to study and trace rudimentary evolutionary processes within the primate lineage. The evolutionary process studied here is the response of the nucleotide frequency ratios to single-strandedness of sites during mitochondrial DNA replication. This response curve is shown to be linear where the slope and intercept of the curve are related to the efficacy of the replication mechanisms and the binding capacity of the gamma-polymerase responsible for mitochondrial DNA replication. A Bayesian analysis of the response curves of the species is conducted and clustering schemes are developed to partition the species based on their response curves. These partitions are then mapped on the phylogenetic tree of the species to trace the evolution of the response curve within the primates.
| Identifer | oai:union.ndltd.org:LSU/oai:etd.lsu.edu:etd-07082004-231554 |
| Date | 09 July 2004 |
| Creators | Raina, Sameer |
| Contributors | Ramachandran Vaidyanathan, David D. Pollock, Subhash Kak |
| Publisher | LSU |
| Source Sets | Louisiana State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lsu.edu/docs/available/etd-07082004-231554/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached herein a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below and in appropriate University policies, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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