In 1913 van Slyke and Meyer showed that amino acids are rapidly absorbed from the blood by the tissues of various animals. The authors found that the intracellular concentrations are in excess of those in the blood and concluded that the mode of entry into the cells must be by a mechanism other than simple diffusion. Almost forty years elapsed before these observations were confirmed by Krebs et al in 1949. In the meantime, microbes bad not been considered as beinq capable of absorbing (transporting) amino acids from their environment. However, a number of perplexing observations concerning amino acid inter-relationships in the nutritional requirements of micro-organisms bad been reported. These observations centred around the ability of structurally related amino acids to permit growth in the presence of inhibitory concentrations of certain amino acids or analogues, or to prevent growth in the presence of an adequate supply of a required amino acid.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.118798 |
| Date | January 1966 |
| Creators | Wilson, Onslow H. |
| Contributors | Scriver, C. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Investigative Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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