Pharmacological treatment of Parkinson's disease involves frequent dose adjustment, complex dose regimes. Also oral antiparkinsonian drugs suffer from the first pass effect, and a variable absorption in the gastrointestinal tract. The transdermal route is an advantageous alternative, as shown by the recent commercialization of a passive patch containing rotigotine (Neupro®). In this work, transdermal iontophoretic delivery of six drugs was performed, using side-by-side diffusion cells. The best candidates for iontophoretic delivery were pramipexole, selegiline, and piribedil. Trihexyphenidyl, entacapone and pergolide are poor candidates and probably would require patches of impractical size.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:505582 |
| Date | January 2009 |
| Creators | Giller, Tomasz |
| Contributors | Delgado-Charro, Maria |
| Publisher | University of Bath |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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