Yes / Endothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We
undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve
morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control
participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001)
and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve
branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute
ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter
correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017,
P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent
association between corneal endothelial cell density, area and perimeter with acute ischemic stroke
and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to
identify patients at risk of acute ischemic stroke. / Qatar National Research Fund Grant BMRP20038654
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/16894 |
| Date | 26 November 2018 |
| Creators | Khan, A., Kamran, S., Akhtar, N., Ponirakis, G., Al-Muhannadi, H., Petropoulos, I.N., Al-Fahdawi, Shumoos, Qahwaji, Rami S.R., Sartaj, F., Babu, B., Wadiwala, M.F., Shuaib, A., Mailk, R.A. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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