<p> The C-B-A ring formation sequence has been adopted towards a total
synthesis of podocarpic acid starting from 2, 7-dihydroxynaphthalene. Experimental
procedures which were developed by other workers have been modified to improve
the yields and the purity of the products. </p> <p> Using naturally occurring podocarpic acid, a reliable procedure has been
explored for the functionalization of C-6 and C-7 positions in order to construct
the 19,6-lactone ring in synthetically satisfactory yields. Catalytic reduction
of the aromatic ring C, after functionalization of ring B, has been investigated
with the aim of developing a pathway towards the elaboration of the C, D ring
system of the kaurane skeleton. </p> / Thesis / Doctor of Philosophy (PhD)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/19859 |
| Date | 05 1900 |
| Creators | Osakwe, Ejiofor |
| Contributors | Bell, R. A., Chemistry |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
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