Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis

Description

Yes / In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models. / Wellcome Trust

Links & Downloads

1. Pinnock A, Shivshetty N, Roy S et al (2017) Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graeve’s Archive for Clinical and Experimental Ophthalmology. 255(2): 333-342.
2. http://hdl.handle.net/10454/11370
3. https://doi.org/10.1007/s00417-016-3546-0

Tags

Ex vivo cornea

Microbial keratitis

Colony-forming units

Corneal model

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11370
Date	2016 November 1914
Creators	Pinnock, A., Shivshetty, N., Roy, S., Rimmer, Stephen, Douglas, I., MacNeil, S., Gary, P.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Published version
Rights	© 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/), CC-BY